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Learn MorePolynucleotide Regenerative Facial
Restore. Regenerate. Renew.
The Next Evolution in Skin Rejuvenation—Now in Provincetown
At The Wellness Lab in Provincetown, we’re excited to offer the Polynucleotide Regenerative Facial, a revolutionary skin rejuvenation treatment designed to repair, regenerate, and deeply revitalize your skin. Polynucleotide (PN) therapy is a cutting-edge, regenerative treatment designed to restore skin at the cellular level—improving texture, elasticity, and overall skin health from within.
Unlike traditional facials or injectables that temporarily mask imperfections, this advanced treatment works by stimulating your body’s natural repair processes, delivering results that are both natural and long-lasting.
What are Polynucleotides?
Polynucleotides (PN) are highly purified DNA fragments, clinically studied for their ability to repair, regenerate, and revitalize skin tissue.
When delivered into the skin, PN acts as a powerful biostimulator—activating cellular repair, boosting collagen production, and enhancing hydration.
The result?
Stronger, healthier, more radiant skin—without adding volume or altering your natural features.
When applied through advanced delivery methods, PN stimulates:
- Stimulates fibroblasts, thus increasing collagen production for firmer more supple skin
- Cellular regeneration to repair damaged tissue
- Angiogenesis (new blood vessel formation) for improved circulation and skin vitality
- Anti-inflammatory effects to soothe and calm irritated
- Supports healing and elasticity
The Wellness Lab utilizes products formulated from wild-harvested, full life-cycle salmon, crafted with the highest purity standards.
Stimulate collagen, accelerate skin repair, and achieve glass-like skin—without fillers.
Reduces fine lines and wrinkles
Improves skin elasticity and firmness
Restores hydration and luminosity
Repairs damaged or scarred skin (including acne scars)
Calms redness and sensitivity
Boosts overall skin texture and tone
The Science Behind Polynucleotides
Polynucleotides (PN) are highly purified, biocompatible DNA fragments derived from salmon, known for their powerful regenerative and tissue-repair properties.
Once delivered into the skin, PN works at a cellular level to stimulate repair, improve skin quality, and restore youthful function—rather than simply masking signs of aging.
How It Works
1. Cellular Regeneration
PN activates fibroblasts—the cells responsible for producing collagen and elastin—helping to rebuild the skin’s structural foundation.
2. Collagen & Elastin Stimulation
By enhancing natural collagen synthesis, PN improves:
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Skin firmness
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Elasticity
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Fine lines and wrinkles
3. Deep Hydration
Polynucleotides have strong water-binding properties, helping the skin retain moisture and achieve a plump, radiant appearance.
4. Anti-Inflammatory & Healing Effects
PN reduces inflammation and accelerates tissue repair, making it ideal for:
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Sensitive or compromised skin
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Post-sun exposure
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Acne or post-procedure recovery
5. Skin Quality Optimization
Rather than adding volume like fillers, PN improves overall skin health—resulting in smoother texture, refined pores, and a natural, lit-from-within glow.
Why Polynucleotides Are Different
Unlike traditional aesthetic treatments that focus on correction, polynucleotides work by restoring skin function at the source.
This makes PN ideal for clients seeking:
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Natural, regenerative results
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Prevention + correction
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Long-term skin health over quick fixes
Advanced Delivery for Maximum Results
At The Wellness Lab, polynucleotides are delivered using advanced infusion techniques to ensure they reach the dermal layer, where true regeneration occurs.
This allows for:
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Greater absorption
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Enhanced collagen stimulation
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More visible, longer-lasting results
The Result
Healthier, stronger, more resilient skin that doesn’t just look better—
it functions better.
Why Clients Choose PN Over Traditional Treatments
Polynucleotides are ideal for those seeking natural, regenerative results without looking “done.”
PN vs. Other Treatments:
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Botox → Temporarily relaxes muscles
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Fillers → Add volume without any biostimulatory effects
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PN Therapy → Restores and regenerates skin from within
This makes PN the perfect choice for clients who value:
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Subtle, natural enhancement
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Long-term skin health
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Preventative + corrective aging
What to Expect
- During the Treatment: You may feel a gentle prickling sensation from the Collagen Induction Therapy (microneedling), but most clients find it comfortable and well-tolerated.
- Immediately After: Your skin may appear slightly pink or flushed, similar to a mild sunburn, which typically subsides within 24-48 hours.
- Results: Visible improvements in skin tone and hydration can be noticed within days, with continued regeneration over 4–6 weeks as collagen rebuilds and skin texture improves.
Frequently Asked Questions
Polynucleotides are highly purified DNA fragments used in regenerative medicine to stimulate skin repair, collagen production, and hydration at a cellular level. They improve overall skin quality rather than simply masking imperfections.
This treatment is often referred to that way online, but in reality, it uses medical-grade, highly refined polynucleotides derived from salmon DNA. The final product is purified, safe, and designed specifically for advanced skin regeneration.
- Botox relaxes muscles to reduce wrinkles
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Fillers add synthetic volume
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Polynucleotides regenerate and repair the skin itself
This treatment improves skin health, texture, and elasticity for natural, long-term results.
PRP uses your own blood and results can vary depending on your body’s condition. Polynucleotides are a consistent, scientifically formulated regenerative treatment, offering more predictable collagen stimulation and skin repair.
At The Wellness Lab, PN is delivered using advanced techniques such as Collagen Induction Therapy (microneedling) or nano-infusion, allowing it to reach the dermal layer where true regeneration occurs.
This treatment is ideal for individuals looking to:
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Improve skin quality and texture
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Address early signs of aging
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Repair sun damage
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Hydrate and rejuvenate dull skin
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Support healing and reduce inflammation
Most clients experience minimal discomfort. A topical numbing agent is be used to ensure a comfortable experience.
For best results, we recommend a series of 3–4 treatments, spaced 4-6weeks apart. Maintenance facials every 3-6 months help keep your skin radiant and healthy.
Downtime is minimal. You may experience:
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Mild redness for 24–48 hours
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Slight sensitivity immediately after treatment
Most clients return to normal activities the same day or next day.
- Initial glow and hydration: within a few days
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Improved texture and tone: within 1–2 weeks
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Collagen and elasticity improvements: over several weeks
Results continue to improve with each treatment.
Yes. Polynucleotides are biocompatible and widely used in regenerative medicine for their healing and anti-inflammatory properties.
Absolutely. PN pairs well with:
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Microneedling
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LED light therapy
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Other regenerative treatments
Your provider will customize a plan based on your goals.
No. This treatment enhances your skin’s natural function—results are subtle, refreshed, and never artificial-looking.
You may not be a candidate if you:
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Are pregnant or breastfeeding
- Have an active skin infection or irritation
* Fish allergy does not automatically disqualify you from receiving this treatment, as polynucleotides are highly purified DNA fragments with no active fish proteins. However, if you have a known fish allergy, we recommend discussing this with your provider during your consultation to ensure this treatment is appropriate for you.
At The Wellness Lab, we merge advanced aesthetics with holistic care. Our team is trained in precision application of regenerative treatments like Polynucleotide Regenerative Facial to ensure optimal results, while keeping your comfort and overall wellness at the center of your experience. We also source our products from companies that adhere to the strict extraction, safety, and purity standards assuring the best possible products and outcomes for our clients.
